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Ketoconazole Antifungal Shampoo addictive CAS No.65277-42-1

Ketoconazole Antifungal Shampoo addictive CAS No.65277-42-1

Ketoconazole is a synthetic antifungal drug. It can highly selectively interfere with the activity of fungal cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol on the fungal cell membrane, damaging the fungal cell membrane and changing its permeability, allowing important intracellular substances to leak out, thereby achieving resistance Fungalaction.

  • Payment:

    TT, LC, Western union
  • Min order:

    25KG
  • CAS No.:

    65277-42-1
  • Usage:

    Shampoo,medicine
  • Appearance:

    A white to almost white powder
  • HS code:

    2933290090
Product Details

Product name:Ketoconazole Antifungal Shampoo addictive CAS No.65277-42-1


Characteristics:

CAS No.65277-42-1

Appearance:Powder

Package:25kg/drum

Usage:Shampoo,medicine

HS Code:2933290090


Description:

This product belongs to the pyrrole antifungal drug. It has antibacterial effect on deep infection fungi such as Candida, Color fungus, Coccidioides, Histoplasma, Sporothrix, etc. It also has antibacterial effect on Trichophyton, etc. Antibacterial activity. This product has poor effect on Aspergillus, Sporothrix Schenkerii, certain spore families, and Mucor. By interfering with the activity of cytochrome P-450, this product inhibits the biosynthesis of ergosterol, the main sterol in the fungal cell membrane, damages the fungal cell membrane and changes its permeability, so that important intracellular materials leak out. This product can inhibit the biosynthesis of fungal triacylglycerol and phospholipid, inhibit the activity of oxidase and peroxidase, and cause the accumulation of hydrogen peroxide in the cell, which leads to cell submicron structure degeneration and cell necrosis. Candida albicans can inhibit the process of its transformation from spores to invasive hyphae.


Packing:25kg/drum


Application:

Shampoo,medicine,lotion


Specification:

TESTS

SPECIFICATION

Description

A white to almost white powder


Solubility

Practically insoluble in water, freely soluble in methylene chloride, soluble in methanol, sparingly soluble in Ethanol

(96%).

Melting point

Between 1480C to 1520C.


Infrared absorption

Infrared absorption spectrum of sample

should be concordant with that of working standard spectrum.

Specific Rotation

Between -1.00 and +1.00 (T= 200C)

Heavy Metals

NMT 0.002%

Loss on drying

NMT 0.5%w/w

Residue on ignition

NMT 0.1%w/w




Related substances by TLC

The principal spot obtained from the test solution has about the same size and Rf value as that obtained from the standard solution and the sum of the intensities of any secondary spots obtained from the test solution does not exceed the intensity of the principal spot obtained from the diluted standard

solution. (NMT: 0.5%)

Assay by titrimetry (on dried basis)

NLT 98.0% w/w & NMT 102.0%w/w

Residual Solvents

Methanol Acetone

Ethyl Acetate


NMT 3000 ppm

MNT 5000 ppm

NMT 5000 ppm

Bulk Density


Untapped Density

For your information

Tapped Density

For your information


Ketoconazole Antifungal

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